INFECTIOUS AGENT

Presence of neutralizing antibodies to HSV were found in the serum of previously infected adults. Only individuals with neutralizing antibodies developed recurrent lesions. Remarkably, measles and rubella antibodies are associated with protection from subsequent episodes of the disease.

National Herpes Hotline 
(919) 361-8488

National Herpes Resource Center 
herpesnet@ashastd.org

 

One significant advance of our understanding of herpes infection was the detection of antigenic differences between HSV types. Already in 1968, antigenic and biologic differences between HSV-1 and HSV-2 were found by Nahmias and Dowdle. The observation was that HSV-1 was more frequently associated with nongenital infection whereas HSV-2 was associated with genital disease.

Infection of epithelial cells in the mucosal surface gives rise to productive replication, resulting in the production of progeny virions, which can spread to infect additional epithelial cells. Virus enters innervating sensory neurons, and nucleocapsids are transported to the neuronal cell body. The viral DNA is released into the neuronal nucleus and circularizes. Circular viral DNA persists in the neuronal cell nucleus, and the latency-associated transcript is expressed. b | Upon reactivation, viral lytic gene expression is initiated, and newly formed capsids are transported to the axonal termini. Infectious virus is released from the axon and infects epithelial cells, resulting in recurrent infection and virus shedding.
 

Oj, I suddenly was attacked by John Blund. Will ferociously continue tomorrow.

God natt, noapte buna, spakujna nocin and good night herpes wherever you are.